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Table 2 Comparative treatment outcomes within 3 months of ovarian stimulation cycles

From: Comparative effectiveness of sildenafil citrate and estradiol valerate as adjuvants during clomiphene citrate-assisted ovarian stimulation cycles in patients with unexplained infertility: a double-blind randomized controlled trial

Treatment outcome

Treatment regimens

  
 

CCSC

N = 166

CC EV

N = 168

P value

RR [95% CI]

Categorical variables

n

%

n

%

  

Biochemical pregnancy

      

Yes

49

29.52

46

27.38

0.333

1.05[0.83–1.33]

No

117

70.48

122

72.62

  

Clinical pregnancy

      

Yes

48

28.92

35

20.83

0.04

1.23[0.98–1.54]

No

118

71.08

133

79.17

  

Ovulation occurrence

      

Yes

163

98.19

155

92.26

0.005*

2.73 [0.98–7.62]

No

3

1.81

13

7.74

  

Endometrial pattern

      

No layering

2

1.21

3

1.79

0.342*

0.79[0.27–2.34]

Distinct 5-line appearance

142

85.54

141

83.93

réf.

1

Hazy 5-line appearance

22

13.25

24

14.28

0.385

0.95[0.68–1.31]

Endometrial vascularization

      

Zone 1–2

6

3.61

10

5.95

0.166

0.74[0.39–1.41]

Zone 3–4

160

96.39

158

94.05

  

Perifollicular blood flow

      

Low-grade

36

21.69

60

35.71

0.002

0.68[0,51-0.91]

High-grade

130

78.31

108

64.29

  

Gradual variables

Mean ± SD

Mean ± SD

Student’s t test

 

Endometrial thickness (mm)

10.39 ± 1.29

10.51 ± 1.61

0.481

 

Day of ovulation triggering (n)

14.72 ± 1.04

15.10 ± 1.22

0.001

 

Number of mature follicles (n)

1.53 ± 0.65

1.52 ± 0.69

0.897

 
  1. CCSC = clomiphene citrate + sildenafil citrate, CCEV = clomiphene citrate + estradiol valerate, SD = standard deviation, RR = relative risk, CI = confidence interval, *Fisher’s exact test