Table 2 Subgroup analysis of outcomes
No of studies | No of participants | Effect estimates | |||
|---|---|---|---|---|---|
Number of oocytes retrieved | Participants ovarian response | Poor responders | 7 | 771 | -0.32 [-0.83, 0.19] |
Normal responders | 1 | 274 | -0.84 [-1.91, 0.23] | ||
Unspecified | 6 | 875 | 0.50 [-0.96, 1.95] | ||
No of flushes | One | 5 | 800 | -0.70 [-1.16, -0.24] | |
Two | 2 | 385 | 0.95 [-1.58, 3.48] | ||
Three | 4 | 439 | -0.14 [-0.67, 0.39] | ||
Four | 1 | 50 | -1.00 [-2.45, 0.45] | ||
Five | 2 | 246 | 0.82 [-3.77, 5.41] | ||
Oocyte/follicle ratio | Participants ovarian response | Poor responders | 2 | 455 | 0.73 [0.28, 1.91] |
Unspecified | 3 | 5596 | 1.37 [0.68, 2.74] | ||
No of flushes | Two | 2 | 4163 | 1.68 [0.64, 4.45] | |
Three | 2 | 455 | 0.73 [0.28, 1.91] | ||
Six | 1 | 1433 | 0.89 [0.69, 1.15] | ||
Number of MII oocytes | Participants ovarian response | Poor responders | 6 | 519 | -0.20 [-0.68, 0.28] |
Normal responders | 1 | 274 | -0.92 [-2.58, 0.74] | ||
Unspecified | 4 | 795 | 0.90 [-0.12, 1.92] | ||
No of flushes | One | 3 | 504 | -0.16 [-1.09, 0.77] | |
Two | 2 | 385 | 0.57 [-1.27, 2.42] | ||
Three | 4 | 439 | -0.17 [-0.70, 0.37] | ||
Four | 1 | 50 | -0.80 [-1.70, 0.10] | ||
Five | 1 | 210 | 2.00 [1.37, 2.63] | ||
Fertilization rate | Participants ovarian response | Poor responders | 1 | 164 | 2.00 [1.07, 3.74] |
Unspecified | 2 | 2924 | 1.20 [0.68, 2.13] | ||
No of flushes | One | 1 | 243 | 2.10 [1.18, 3.71] | |
Two | 2 | 2924 | 1.20 [0.68, 2.13] | ||
Five | 1 | 164 | 2.00 [1.07, 3.74] | ||
Implantation rate | Participants ovarian response | Poor responders | 4 | 413 | 0.60 [0.16, 2.28] |
Normal responders | 1 | 808 | 1.17 [0.86, 1.61] | ||
Unspecified | 1 | 220 | 1.15 [0.64, 2.06] | ||
No of flushes | One | 2 | 867 | 0.83 [0.30, 2.32] | |
Two | 1 | 220 | 1.15 [0.64, 2.06] | ||
Three | 2 | 250 | 1.63 [0.34, 7.89] | ||
Four | 1 | 104 | 0.10 [0.02, 0.44] | ||
Clinical pregnancy rate | Participants ovarian response | Poor responders | 5 | 617 | 0.90 [0.40, 2.01] |
Normal responders | 1 | 274 | 1.28 [0.80, 2.07] | ||
Unspecified | 5 | 651 | 1.47 [0.94, 2.28] | ||
No of flushes | One | 3 | 726 | 1.25 [0.90, 1.74] | |
Two | 2 | 317 | 2.08 [0.62, 6.95] | ||
Three | 2 | 151 | 1.67 [0.24, 11.67] | ||
Four | 1 | 50 | 0.07 [0.01, 0.64] | ||
Five | 2 | 198 | 0.95 [0.40, 2.23] | ||
Six | 1 | 100 | 1.11 [0.45, 2.75] | ||
Ongoing/livebirth rate | Participants ovarian response | Poor responders | 7 | 727 | 0.85 [0.52, 1.38] |
Normal responders | 1 | 173 | 1.18 [0.64, 2.16] | ||
Unspecified | 3 | 366 | 1.23 [0.79, 1.91] | ||
No of flushes | One | 4 | 655 | 1.10 [0.76, 1.60] | |
Two | 1 | 132 | 1.17 [0.58, 2.38] | ||
Three | 3 | 231 | 1.26 [0.55, 2.90] | ||
Four | 1 | 50 | 0.17 [0.02, 1.55] | ||
Five | 2 | 198 | 0.85 [0.34, 2.11] | ||
Time of procedure | Participants ovarian response | Poor responders | 5 | 311 | 147.67 [73.08, 222.26] |
Normal responders | 1 | 274 | 255.60 [223.94, 287.26] | ||
Unspecified | 2 | 400 | 210.84 [81.49, 340.19] | ||
No of flushes | One | 3 | 504 | 241.99 [194.99, 288.98] | |
Two | 1 | 200 | 144.00 [79.32, 208.68] | ||
Three | 3 | 231 | 141.59 [38.34, 244.84] | ||
Four | 1 | 50 | 138.00 [66.89, 209.11] | ||
Cancellation rate | Participants ovarian response | Poor responders | 3 | 382 | 0.63 [0.39, 1.00] |
Normal responders | 1 | 274 | 0.83 [0.28, 2.44] | ||
Unspecified | 1 | 200 | 0.70 [0.27, 1.83] | ||
No of flushes | One | 3 | 726 | 0.61 [0.39, 0.95] | |
Three | 1 | 80 | 1.00 [0.39, 2.55] | ||
Four | 1 | 50 | 0.32 [0.01, 8.25] |